上海
埃萬妥單抗聯合方案中國獲批，為肝轉移患者帶來顯著生存獲益
*以下內容僅供醫療衛生專業人士瀏覽。
審批編碼：CP-555412
批準分發日期：2025/11/28
有效期：2026/11/28
參考文獻：
[1]Zhou F, et al. The changing treatment landscape of EGFR-mutant non-small-cell lung cancer. Nat Rev Clin Oncol. 2025;22(2):95-116.
[2]Niu FY, Zhou Q, Yang JJ, et al. Distribution and prognosis of uncommon metastases from non-small cell lung cancer. BMC Cancer. 2016;16:149. Published 2016 Feb 24.
[3]Cho BC, et al. Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC. N Engl J Med. 2024;391(16):1486-1498.
[4]Ouint LE, et al. Distribution of distant metastases from newly diagnosed non - small cell lung cancer[J] .The Annals of Thoracic Surgery,1996,62(1):246-250
[5]Ren Y, et al. Prognostic effect of liver metastasis in lung cancer patients with distant metastasis. Oncotarget 2016;7:53245-53253
[6]Planchard D, et al; FLAURA2 Investigators. Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC. N Engl J Med. 2023 Nov 23;389(21):1935-1948.
[7]Felip E, et al. Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease: a secondary analysis from MARIPOSA. Ann Oncol. 2024;35(9):805-816.
[8]Enriqueta Felip, et al. mivantamab plus chemotherapy vs chemotherapy as first-line treatment in EGFR exon 20 insertion-mutated advanced NSCLC: Analysis of post-progression endpoints from PAPILLON. 2024 ELCC 2MO
[9]Spira AI, et al. Risk Factors Associated with Suboptimal Real-World Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Treated with Front-Line Recommended Therapy. Adv Ther. 2025;42(7):3547-3561.
[10]Yu HA, et al. Detection of MET amplification (METamp) in patients with EGFR mutant (m) NSCLC after first-line (1L) osimertinib.. JCO 41, 9074-9074(2023).
[11]Moores SL, et al. A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors. Cancer Res. 2016;76(13):3942-3953.
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